First Choice may refer to:
First Choice (group), an American vocal trio, active 1971–1984
First Choice Emergency Room, a healthcare company based in Flower Mound, Texas
First Choice Liquor, an Australian retailer
First Choice (travel firm), travel firm owned by TUI Group
First Choice Airways, its former in-house airline
First Choice Haircutters, a Canadian hairdressing company
Crave, a pay TV service in Canada, known simply as "First Choice" 1983–84 and 1989–93
First Choice Superchannel, a service jointly operated with Superchannel (Movie Central) from 1984 to 1989
Pfs:First Choice, a 1980s word processing program
